The following are two popular prescription medications that are often prescribed for the treatment of hypercholesterolaemia:
Raloxifeneis prescribed to treat high cholesterol, as well as certain types of high blood pressure and other cardiovascular conditions.
Crestoris an anti-inflammatory drug that reduces the production of LDL cholesterol by blocking the enzyme that prevents cholesterol from being converted to LDL.
Crestor CRis used to lower levels of high-density lipoprotein (HDL) in the blood, which helps to reduce the risk of cardiovascular disease.
Rosuvastatinis an antidiabetic drug that helps increase the number of LDL-cholesterol cells in the liver. This makes it a valuable treatment option for patients who have liver disease.
Ricabrutinibis a statin that is often used to manage high cholesterol and other cardiovascular conditions. It is a brand-name drug, and it has been in clinical use for a long time.
Tadacipis a prescription medicine that is used to treat certain types of liver diseases. It is one of the most widely used statins in the US and is also prescribed for other conditions, including hypertension and hypercholesterolaemia.
Valsartanis a calcium channel blocker that works by relaxing the blood vessels in your heart and also increasing blood flow to the lungs. It is available in many strengths and can be taken daily.
is an anti-cholesterol medication. It is used to treat high cholesterol and other cardiovascular conditions.
Read on to learn more about Crestor CR, its uses, benefits, side effects, and more.
Crestor CR works by blocking the action of a key enzyme in the liver, called HMG-CoA reductase. This enzyme converts cholesterol into its “bad” form, HMG-CoA, and this helps lower cholesterol levels.
This may reduce the severity of symptoms associated with high cholesterol, such as low blood pressure, heart attacks, and strokes, but it does not cure the underlying cause of cholesterol plaque buildup.
Crestor CR is taken once daily. It is usually taken with or without food. It can be taken with or without food, but it is important to avoid heavy meals that contain high levels of cholesterol. If you miss a dose, take it as soon as you remember. Continue the regular dosing schedule, even if you start feeling better, with your doctor’s advice. It is important to continue taking CR at the same time every day to maintain the medication’s effectiveness.
Most people with high cholesterol do not experience any side effects. However, some people may experience mild side effects that can be treated with a lower dose of Crestor CR.
Common side effects of Crestor CR include:
Less common side effects include:
If you experience any side effects that bother you, talk to your doctor. Your doctor can assess whether Crestor CR is safe for you to take.
Background:The safety of Crestor® is not well established in Australia. A large number of patients treated with Crestor® are experiencing adverse events, including acute renal injury and mortality. We conducted a retrospective analysis of the pharmacokinetics of Crestor® in adult patients, and compared the results to a similar database of patients receiving standard care in Australia. This is an observational study using data from the national Adverse Drug Reactions Monitoring System (ADRSM) database. This analysis was performed using the Health Professionals Follow-Up Information System, which monitors drug safety throughout the year. We did not collect data on patients who had not received Crestor® in Australia, or who had received it before the study was started. Data were collected on patients who were prescribed Crestor® at a time before initiation of therapy. In total, 3,531 patients received Crestor® at the same time and were followed up every 6 months. We compared the safety and adverse events of Crestor® to that of standard care in patients with a prior history of adverse events, and in patients who were treated with standard care in Australia. We also conducted an analysis of the pharmacokinetic profiles of Crestor® in patients with a prior history of adverse events. The following adverse events were observed as either increased or decreased in frequency or severity by this analysis: (1) headache; (2) insomnia; (3) abdominal pain; (4) nausea/vomiting; (5) insomnia; (6) fatigue; and (7) dizziness. These adverse events were significantly more common in the Crestor® group than in the standard care group.
The safety of Crestor® was evaluated for all patients. The analysis of the pharmacokinetic data showed that all patients receiving Crestor® had a similar degree of renal clearance (F0.5), and that the half-life of Crestor® was similar to that of standard care. The mean plasma concentration-time profiles of Crestor® and standard care were similar, with a mean time of half-life of about 2.6 and 2.3, respectively. The mean plasma concentration-time profiles of Crestor® and standard care were similar, with a mean half-life of about 2.2 and 2.6, respectively. There was a difference in the plasma clearance of Crestor® between the Crestor® group and the standard care group, and that the Crestor® group had a lower mean half-life than the standard care group. There were no differences in the mean half-life of Crestor® among the patients in the treatment groups. There was a similar tendency to a similar trend in the plasma concentrations of Crestor® and standard care. We concluded that the results of this study can be used to guide prescribing of Crestor® in patients with renal impairment. Patients receiving Crestor® should be monitored for adverse events and their treatment should be adjusted accordingly.There were no significant differences between Crestor® and standard care in terms of the mean plasma clearance of Crestor® and the mean half-life of Crestor® (compared to standard care) (F=3.19, P=0.096). The results of this analysis did not show differences between Crestor® and standard care. Patients in the Crestor® group had a mean plasma concentration-time profile of approximately 2.2 hours, which was longer than that of standard care. There was also a statistically significant difference in the plasma clearance of Crestor® between the Crestor® group and the standard care group, with a mean half-life of approximately 2.6 hours. The mean plasma concentration-time profiles of Crestor® and standard care were similar, with a mean half-life of about 1.5 and about 2.6, respectively. The Crestor® group had a lower mean half-life than the standard care group. There were no differences in the plasma clearance of Crestor® between the Crestor® group and the standard care group.The results of this study showed no significant differences between the Crestor® and standard care groups in terms of adverse events.
Keywords:Acute renal failure; Crestor®; Adverse events; Adverse effects
Actions:This study was performed on patients with a prior history of adverse events.
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Crestor (rosuvastatin calcium) is an oral medication used to treat high cholesterol and triglycerides (total and LDL) and high blood pressure. Crestor is an oral medication that has been shown to be safe and effective in lowering high cholesterol levels. Crestor was approved by the Food and Drug Administration (FDA) in 1997.
For the treatment of:
Adult hypercholesterolaemia is defined as an absolute mmol/l of blood glucose level greater than 6.0 mmol/l. Adult hypercholesterolaemia has been shown to occur in approximately 2% of patients as compared to 1% of patients in the general population. The estimated incidence of hypercholesterolaemia in adults and adolescents is 5% to 10%.
Lowers HbA1c is also commonly used to treat adults with hypocholesterolaemia (HAP).
Cholesterol is a key factor in the development and progression of atherosclerosis (the buildup of plaque in the arteries) and is a key determinant of atherosclerotic disease. Lower cholesterol levels and more pronounced atherosclerotic changes are associated with an increased risk of cardiovascular events and mortality. Cholesterol is a lipid-soluble, white substance that is found in most foods and drinks. Common foods and beverages that may contain fat include citrus, tomato, red wine, orange, mango, grapefruit and sweet fruits such as orange, mango, mangoes, grapefruit, grapefruit juice, and white wine. In fact, cholesterol levels are also increased in patients with dyslipidemia.
References:1. Lipitor, J. J., et al.
Crestor works by reducing a certain enzyme within the body that produces cholesterol. It belongs to a class of medications called statins.
Cholesterol is a form of lipid, a waxy substance that helps your body make cells, vitamins, and certain hormones. It is not inherently bad. Your liver produces an enzyme that synthesizes cholesterol to help with the above healthy functions. Additional cholesterol is introduced to the body through certain foods like meat, poultry, and dairy products.
There are two types of cholesterol: high-density lipoproteins (HDLs) and low-density lipoproteins (LDLs). LDLs carry cholesterol throughout the body, delivering cholesterol to cells that need it. HDLs carry excess LDLs back to the liver, where they are broken down and flushed from the body. While LDLs play a key role in cell health, they build up when the body has more cholesterol than the cells need. This buildup turns into plaque in the arteries (blood vessels). As plaque covers the artery walls, the blood vessels become narrow. This makes it harder for blood to flow through the body, which can lead to heart disease and heart failure.
Statins work by reducing the production of cholesterol in the liver, which lowers the overall cholesterol levels in the body. Not only do statins decrease levels of LDLs in the body, but they can also raise the level of HDLs in the body. In effect, they keep the body from making too much of the “bad” cholesterol that builds up in arteries while increasing the amount of “good” cholesterol that carries the “bad” out of the body. This dual action has been shown, along with diet and exercise, to lower overall cholesterol levels in patients effectively.
Crestor temporarily raises levels of “bad” cholesterol by over four-fold in a safe manner. This means the overall effectiveness of this medicine goes up less than was used to. As a result, the side effects of this medicine go away. If you have had a heart attack, stroke, or other medical condition, talk to your doctor before you take this medicine. If you have any of these conditions, avoid or limit alcohol use.In addition, speak with your doctor before you take Crestor. Your doctor can help you identify any underlying health conditions that could take a turn for the better. By going over these factors, you can better understand what may be causing your current health conditions. This also may reduce the risk of side effects.
Crestor 10 mg Tablet contains Rosuvastatin 10 mg which is used in the treatment of high cholesterol. Crestor 10 mg Tablet is a lipid-lowering medication (statin). It works by blocking an enzyme that is required in the body to make cholesterol. It thus lowers “bad” cholesterol (LDL) triglycerides and raises “good” cholesterol (HDL).
Dosage and Administration. Crestor 10 mg Tablet is available in the form of a liquid or tablets. The recommended dose of Crestor 10 mg Tablet is one tablet taken before or 4 hours after food. However, you should not take it more than once a day. The medicine should be administered by your doctor. The dose should not be exceeded in every day use. Follow the dosage instructions provided by your doctor. His/ her direction is to use the tablets only as per the doctor's advice and to consult with your doctor if any side effects or concerns appear. Consult your doctor or pharmacist for more details.
Stade de France Pharmacy